| 1 | -- | 3 | Jamie Davies, Michael Grinfeld, Steven D. Webb. Introduction to the special issue |
| 5 | -- | 18 | Britta Göbel, Dirk Langemann. Systemic investigation of a brain-centered model of the human energy metabolism |
| 19 | -- | 29 | Chris McCaig, Mike Begon, Rachel Norman, Carron Shankland. A rigorous approach to investigating common assumptions about disease transmission |
| 31 | -- | 43 | Hugh R. MacMillan, Michael J. McConnell. Seeing beyond the average cell: branching process models of cell proliferation, differentiation, and death during mouse brain development |
| 45 | -- | 54 | Oliver Ruebenacker, Michael L. Blinov. Using views of Systems Biology Cloud: application for model building |
| 55 | -- | 69 | Svetoslav Nikolov, Julio Vera, Ulf Schmitz, Olaf Wolkenhauer. microRNA regulation in cancer signalling networks |
| 71 | -- | 89 | Peter Schuster. Mathematical modeling of evolution. Solved and open problems |