Journal: Briefings in Bioinformatics

Volume 20, Issue 6

1957 -- 1971Rajeev K. Azad, Vladimir Shulaev. Metabolomics technology and bioinformatics for precision medicine
1972 -- 1980Juan Wang, Maozu Guo. A review of metrics measuring dissimilarity for rooted phylogenetic networks
1981 -- 1996Jeff Gauthier, Antony T. Vincent, Steve J. Charette, Nicolas Derome. A brief history of bioinformatics
1997 -- 2008Clare Horscroft, Sarah Ennis, Reuben J. Pengelly, Timothy J. Sluckin, Andrew Collins. Sequencing era methods for identifying signatures of selection in the genome
2009 -- 2027Siyu Han, Yanchun Liang 0001, Qin Ma 0003, Yangyi Xu, Yu Zhang, Wei Du 0002, Cankun Wang, Ying Li 0004. LncFinder: an integrated platform for long non-coding RNA identification utilizing sequence intrinsic composition, structural information and physicochemical property
2028 -- 2043Dai-Hai Nguyen, Canh Hao Nguyen, Hiroshi Mamitsuka. Recent advances and prospects of computational methods for metabolite identification: a review with emphasis on machine learning approaches
2044 -- 2054Adam McDermaid, Brandon Monier, Jing Zhao, Bingqiang Liu, Qin Ma 0003. Interpretation of differential gene expression results of RNA-seq data: review and integration
2055 -- 2065Johannes Brägelmann, Justo Lorenzo Bermejo. A comparative analysis of cell-type adjustment methods for epigenome-wide association studies based on simulated and real data sets
2066 -- 2087Chen Wang, Lukasz A. Kurgan. Review and comparative assessment of similarity-based methods for prediction of drug-protein interactions in the druggable human proteome
2088 -- 2097Xun Chen, Jason Kost, Dawei Li. Comprehensive comparative analysis of methods and software for identifying viral integrations
2098 -- 2115Wenliang Zhang, Haiyue Zhang, Huan Yang, Miaoxin Li, Zhi Xie, Weizhong Li 0001. Computational resources associating diseases with genotypes, phenotypes and exposures
2116 -- 2129Kleber Padovani de Souza, João Carlos Setubal, André Carlos Ponce de Leon Ferreira de Carvalho, Guilherme Oliveira, Annie Chateau, Ronnie Alves. Machine learning meets genome assembly
2130 -- 2140Fulong Yu, Fei Quan, Jinyuan Xu, Yan Zhang, Yi Xie, Jingyu Zhang, Yujia Lan, Huating Yuan, Hongyi Zhang, Shujun Cheng, Yun Xiao 0001, Xia Li 0004. Breast cancer prognosis signature: linking risk stratification to disease subtypes
2141 -- 2149Hongyan Yin, Mengwei Li, Lin Xia, Chaozu He, Zhang Zhang 0002. Computational determination of gene age and characterization of evolutionary dynamics in human
2150 -- 2166Fuyi Li, Yanan Wang, Chen Li 0021, Tatiana T. Marquez-Lago, André Leier, Neil D. Rawlings, Gholamreza Haffari, Jerico Nico De Leon Revote, Tatsuya Akutsu, Kuo-Chen Chou, Anthony W. Purcell, Robert N. Pike, Geoffrey I. Webb, A. Ian Smith, Trevor Lithgow, Roger J. Daly, James C. Whisstock, Jiangning Song. Twenty years of bioinformatics research for protease-specific substrate and cleavage site prediction: a comprehensive revisit and benchmarking of existing methods
2167 -- 2184Misagh Naderi, Jeffrey Mitchell Lemoine, Rajiv Gandhi Govindaraj, Omar Kana, Wei Pan Feinstein, Michal Brylinski. Binding site matching in rational drug design: algorithms and applications
2185 -- 2199Yanju Zhang, Ruopeng Xie, Jiawei Wang, André Leier, Tatiana T. Marquez-Lago, Tatsuya Akutsu, Geoffrey I. Webb, Kuo-Chen Chou, Jiangning Song. Computational analysis and prediction of lysine malonylation sites by exploiting informative features in an integrative machine-learning framework
2200 -- 2216Fentaw Abegaz, Kridsadakorn Chaichoompu, Emmanuelle Génin, David W. Fardo, Inke R. König, Jestinah M. Mahachie John, Kristel Van Steen. Principals about principal components in statistical genetics
2217 -- 2223Zhiyu Hao, Li Jiang, Jin Gao, Jinhua Ye, Jingli Zhao, Shuling Li, Runqing Yang. Quick approximation of threshold values for genome-wide association studies
2224 -- 2235Saurav Mallik, Gabriel J. Odom, Zhen Gao, Lissette Gomez, Xi Chen, Lily Wang. An evaluation of supervised methods for identifying differentially methylated regions in Illumina methylation arrays
2236 -- 2252Wan-Yu Lin, Ching-Chieh Huang, Yu-Li Liu, Shih-Jen Tsai, Po-Hsiu Kuo. Polygenic approaches to detect gene-environment interactions when external information is unavailable
2253 -- 2266Min Li 0007, Hao Gao, Jianxin Wang, Fang-Xiang Wu. Control principles for complex biological networks
2267 -- 2290Zhen Chen, Xuhan Liu, Fuyi Li, Chen Li 0021, Tatiana T. Marquez-Lago, André Leier, Tatsuya Akutsu, Geoffrey I. Webb, Dakang Xu, Alexander Ian Smith, Lei Li 0013, Kuo-Chen Chou, Jiangning Song. Large-scale comparative assessment of computational predictors for lysine post-translational modification sites
2291 -- 2298Yan Zhao, Yujie Ning, Feng Zhang, Miao Ding, Yan Wen, Liang Shi, Kunpeng Wang, Mengnan Lu, Jingyan Sun, Menglu Wu, Bolun Cheng, Mei Ma, Lu Zhang, Shiqiang Cheng, Hui Shen, Qing Tian, Xiong Guo, Hong-Wen Deng. PCA-based GRS analysis enhances the effectiveness for genetic correlation detection
2299 -- 2305Maciej Blaszczyk, Maciej Pawel Ciemny, Andrzej Kolinski, Mateusz Kurcinski, Sebastian Kmiecik. Protein-peptide docking using CABS-dock and contact information
2306 -- 2315Meng Zou, Rui Jin, Kin Fai Au. Revealing tumor heterogeneity of breast cancer by utilizing the linkage between somatic and germline mutations
2316 -- 2326Taiyun Kim, Irene Rui Chen, Yingxin Lin, Andy Yi-Yang Wang, Jean Yee Hwa Yang, Pengyi Yang. Impact of similarity metrics on single-cell RNA-seq data clustering
2327 -- 2333Zhidong Tang, Xuecang Li, Jianmei Zhao, Fengcui Qian, Chenchen Feng, Yanyu Li, Jian Zhang, Yong Jiang, Yongsan Yang, Qiuyu Wang, Chunquan Li. TRCirc: a resource for transcriptional regulation information of circRNAs

Volume 20, Issue 5

1597 -- 1606Shao-Ping Shi, Lina Wang, Man Cao, Guodong Chen, Jialin Yu. Proteomic analysis and prediction of amino acid variations that influence protein posttranslational modifications
1607 -- 1620Georgina Stegmayer, Leandro E. Di Persia, Mariano Rubiolo, Matias Gerard, Milton Pividori, Cristian A. Yones, Leandro A Bugnon, Tadeo Rodriguez, Jonathan Raad, Diego H. Milone. Predicting novel microRNA: a comprehensive comparison of machine learning approaches
1621 -- 1638Tingting Shao, Guangjuan Wang, Hong Chen, Yunjin Xie, Xiyun Jin, Jing Bai, Juan Xu, Xia Li, Jian Huang, Yan Jin, Yongsheng Li. Survey of miRNA-miRNA cooperative regulation principles across cancer types
1639 -- 1654Elena Rojano, Pedro Seoane, Juan A. G. Ranea, James Richard Perkins. Regulatory variants: from detection to predicting impact
1655 -- 1668Alicia Amadoz, Marta R. Hidalgo, Cankut Çubuk, José Carbonell-Caballero, Joaquín Dopazo. A comparison of mechanistic signaling pathway activity analysis methods
1669 -- 1684Yu Bao, Simone Marini, Takeyuki Tamura, Mayumi Kamada, Shingo Maegawa, Hiroshi Hosokawa, Jiangning Song, Tatsuya Akutsu. Toward more accurate prediction of caspase cleavage sites: a comprehensive review of current methods, tools and features
1685 -- 1698Claire Bertelli, Keith E. Tilley, Fiona S. L. Brinkman. Microbial genomic island discovery, visualization and analysis
1699 -- 1708Francesco Pappalardo 0001, Giulia Russo, Flora Musuamba Tshinanu, Marco Viceconti. In silico clinical trials: concepts and early adoptions
1709 -- 1724Ephifania Geza, Jacquiline W. Mugo, Nicola J. Mulder, Ambroise Wonkam, Emile R. Chimusa, Gaston K. Mazandu. A comprehensive survey of models for dissecting local ancestry deconvolution in human genome
1725 -- 1733Zhongneng Xu, Shuichi Asakawa. Physiological RNA dynamics in RNA-Seq analysis
1734 -- 1753Raziur Rahman, Saugato Rahman Dhruba, Kevin Matlock, Carlos De Niz, Souparno Ghosh, Ranadip Pal. Evaluating the consistency of large-scale pharmacogenomic studies
1754 -- 1768Dinanath Sulakhe, Mark D'Souza, Sheng Wang 0001, Sandhya Balasubramanian, Prashanth Athri, Bingqing Xie, Stefan Canzar, Gady Agam, T. Conrad Gilliam, Natalia Maltsev. Exploring the functional impact of alternative splicing on human protein isoforms using available annotation sources
1769 -- 1780Mikhail G. Dozmorov. Disease classification: from phenotypic similarity to integrative genomics and beyond
1781 -- 1794Qi Chen, Xianwen Meng, Qi Liao, Ming Chen 0013. Versatile interactions and bioinformatics analysis of noncoding RNAs
1795 -- 1811Gaye Lightbody, Valeriia Haberland, Fiona Browne, Laura Taggart, Huiru Zheng, Eileen Parkes, Jaine K. Blayney. Review of applications of high-throughput sequencing in personalized medicine: barriers and facilitators of future progress in research and clinical application
1812 -- 1825Chunjie Jiang, Na Ding, Junyi Li, Xiyun Jin, Lili Li, Tao Pan, Caiqin Huo, Yongsheng Li, Juan Xu, Xia Li. Landscape of the long non-coding RNA transcriptome in human heart
1826 -- 1835Dongyang Liu, Guangpeng Li, Yongchun Zuo. Function determinants of TET proteins: the arrangements of sequence motifs with specific codes
1836 -- 1852Liang Chen, Liisa Heikkinen, Changliang Wang, Yang Yang, Huiyan Sun, Garry Wong. Trends in the development of miRNA bioinformatics tools
1853 -- 1864Seowon Choi, Hyun Woo Kim, Jin-Wu Nam. The small peptide world in long noncoding RNAs
1865 -- 1877Yongjing Liu, Liangyu Fu, Kerstin Kaufmann, Dijun Chen, Ming Chen 0013. A practical guide for DNase-seq data analysis: from data management to common applications
1878 -- 1912Ahmet Süreyya Rifaioglu, Heval Atas, Maria Jesus Martin, Rengül Çetin-Atalay, Volkan Atalay, Tunca Dogan. Recent applications of deep learning and machine intelligence on in silico drug discovery: methods, tools and databases
1913 -- 1924Yang-Jun Wen, Ya-Wen Zhang, Jin Zhang, Jian-Ying Feng, Jim M. Dunwell, Yuan-Ming Zhang. An efficient multi-locus mixed model framework for the detection of small and linked QTLs in F2
1925 -- 1933Zhenyu Yue, Le Zhao, Na Cheng, Hua Yan, Junfeng Xia. dbCID: a manually curated resource for exploring the driver indels in human cancer
1934 -- 1943Zuqi Zuo, Yonghao Jin, Wen Zhang, Yichen Lu, Bin Li, Kun Qu. ATAC-pipe: general analysis of genome-wide chromatin accessibility
1944 -- 1955Oliver Schmitt 0001, Peter Eipert, Sebastian Schwanke, Felix Lessmann, Jennifer Meinhardt, Julia Beier, Kanar Kadir, Adrian Karnitzki, Linda Sellner, Ann-Christin Klünker, Frauke Ruß, Jörg Jenssen. Connectome verification: inter-rater and connection reliability of tract-tracing-based intrinsic hypothalamic connectivity
1956 -- 0. Corrigendum to: How trees allocate carbon for optimal growth: insight from a game-theoretic model

Volume 20, Issue 4

1063 -- 1070Michael Y. Galperin, David M. Kristensen, Kira S. Makarova, Yuri I. Wolf, Eugene V. Koonin. Microbial genome analysis: the COG approach
1071 -- 1084Claudine Médigue, Alexandra Calteau, Stéphane Cruveiller, Mathieu Gachet, Guillaume Gautreau, Adrien Josso, Aurélie Lajus, Jordan Langlois, Hugo Pereira, Rémi Planel, David Roche, Johan Rollin, Zoé Rouy, David Vallenet. MicroScope - an integrated resource for community expertise of gene functions and comparative analysis of microbial genomic and metabolic data
1085 -- 1093Peter D. Karp, Richard Billington, Ron Caspi, Carol A. Fulcher, Mario Latendresse, Anamika Kothari, Ingrid M. Keseler, Markus Krummenacker, Peter E. Midford, Quang Ong, Wai Kit Ong, Suzanne M. Paley, Pallavi Subhraveti. The BioCyc collection of microbial genomes and metabolic pathways
1094 -- 1102Dionysios A. Antonopoulos, Rida Assaf, Ramy Karam Aziz, Thomas S. Brettin, Christopher Bun, Neal Conrad, James J. Davis, Emily M. Dietrich, Terry Disz, Svetlana Gerdes, Ronald W. Kenyon, Dustin Machi, Chunhong Mao, Daniel E. Murphy-Olson, Eric K. Nordberg, Gary J. Olsen, Robert Olson, Ross A. Overbeek, Bruce D. Parrello, Gordon D. Pusch, John Santerre, Maulik Shukla, Rick L. Stevens, Margo VanOeffelen, Veronika Vonstein, Andrew S. Warren, Alice R. Wattam, Fangfang Xia, Hyun Seung Yoo. PATRIC as a unique resource for studying antimicrobial resistance
1103 -- 1113Kai Blin, Hyun Uk Kim, Marnix H. Medema, Tilmann Weber. Recent development of antiSMASH and other computational approaches to mine secondary metabolite biosynthetic gene clusters
1114 -- 1124Hao Luo 0002, Chun-Lan Quan, Chong Peng, Feng Gao 0001. Recent development of Ori-Finder system and DoriC database for microbial replication origins
1125 -- 1136Florian P. Breitwieser, Jennifer Lu, Steven L. Salzberg. A review of methods and databases for metagenomic classification and assembly
1140 -- 1150Nathan D. Olson, Todd J. Treangen, Christopher Michael Hill, Victoria Cepeda-Espinoza, Jay Ghurye, Sergey Koren, Mihai Pop. Metagenomic assembly through the lens of validation: recent advances in assessing and improving the quality of genomes assembled from metagenomes
1151 -- 1159Folker Meyer, Saurabh Bagchi, Somali Chaterji, Wolfgang Gerlach, Ananth Grama, Travis Harrison, Tobias Paczian, William L. Trimble, Andreas Wilke. MG-RAST version 4 - lessons learned from a decade of low-budget ultra-high-throughput metagenome analysis
1160 -- 1166Kazutaka Katoh, John Rozewicki, Kazunori D. Yamada. MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization
1167 -- 1180David R. Gilbert, Monika Heiner, Yasoda Jayaweera, Christian Rohr. Towards dynamic genome-scale models
1181 -- 1192Lionel Morgado, Frank Johannes. Computational tools for plant small RNA detection and categorization
1193 -- 1204Yongsheng Li, Xiyun Jin, Zishan Wang, Lili Li, Hong Chen, Xiaoyu Lin, Song Yi, Yunpeng Zhang, Juan Xu. Systematic review of computational methods for identifying miRNA-mediated RNA-RNA crosstalk
1205 -- 1214Jincheol Park, Shili Lin. Evaluation and comparison of methods for recapitulation of 3D spatial chromatin structures
1215 -- 1221Gerhard Mayer, Christian Quast, Janine Felden, Matthias Lange 0001, Manuel Prinz, Alfred Pühler, Chris Lawerenz, Uwe Scholz, Frank Oliver Glöckner, Wolfgang Müller 0001, Katrin Marcus, Martin Eisenacher. A generally applicable lightweight method for calculating a value structure for tools and services in bioinformatics infrastructure projects
1222 -- 1237Brian B. Luczak, Benjamin T. James, Hani Z. Girgis. A survey and evaluations of histogram-based statistics in alignment-free sequence comparison
1238 -- 1249Arnau Montagud, Pauline Traynard, Loredana Martignetti, Eric Bonnet, Emmanuel Barillot, Andrei Zinovyev, Laurence Calzone. Conceptual and computational framework for logical modelling of biological networks deregulated in diseases
1250 -- 1268Jian Zhang 0020, Zhiqiang Ma, Lukasz A. Kurgan. Comprehensive review and empirical analysis of hallmarks of DNA-, RNA- and protein-binding residues in protein chains
1269 -- 1279Giulia Tini, Luca Marchetti, Corrado Priami, Marie-Pier Scott-Boyer. Multi-omics integration - a comparison of unsupervised clustering methodologies
1280 -- 1294Bin Liu 0014. BioSeq-Analysis: a platform for DNA, RNA and protein sequence analysis based on machine learning approaches
1295 -- 1307Ruiping Wang 0002, Yue Han, Zhangxiang Zhao, Fan Yang, Tingting Chen, Wenbin Zhou, Xianlong Wang, Lishuang Qi, Wenyuan Zhao, Zheng Guo 0002, Yunyan Gu. Link synthetic lethality to drug sensitivity of cancer cells
1308 -- 1321Yongjun Zhu, Olivier Elemento, Jyotishman Pathak, Fei Wang 0001. Drug knowledge bases and their applications in biomedical informatics research
1322 -- 1328Qin Tang, Qiong Zhang, Yao Lv, Ya-Ru Miao, An-Yuan Guo. SEGreg: a database for human specifically expressed genes and their regulations in cancer and normal tissue
1329 -- 1336Florencio Pazos, Monica Chagoyen. Characteristics and evolution of the ecosystem of software tools supporting research in molecular biology
1337 -- 1357Ali Ezzat, Min Wu 0008, Xiao-Li Li, Chee Keong Kwoh. Computational prediction of drug-target interactions using chemogenomic approaches: an empirical survey
1358 -- 1375Fernando Carazo, Juan P. Romero, Angel Rubio. Upstream analysis of alternative splicing: a review of computational approaches to predict context-dependent splicing factors
1376 -- 1383Paul Medvedev. Modeling biological problems in computer science: a case study in genome assembly
1384 -- 1394Alessandra Dal Molin, Barbara Di Camillo. How to design a single-cell RNA-sequencing experiment: pitfalls, challenges and perspectives
1395 -- 1402Andrés Zalguizuri, Gustavo Caetano-Anollés, Viviana Claudia Lepek. Phylogenetic profiling, an untapped resource for the prediction of secreted proteins and its complementation with sequence-based classifiers in bacterial type III, IV and VI secretion systems
1403 -- 1419Junpeng Zhang, Thuc Duy Le, Lin Liu 0003, Jiuyong Li. Inferring and analyzing module-specific lncRNA-mRNA causal regulatory networks in human cancer
1420 -- 1433Shasha Li, Shuaishuai Teng, Junquan Xu, Guannan Su, Yu Zhang, Jianqing Zhao, Suwei Zhang, Haiyan Wang, Wenyan Qin, Zhi John Lu, Yong Guo, Qianyong Zhu, Dong Wang. Microarray is an efficient tool for circRNA profiling
1434 -- 1448Igor F. Tsigelny. Artificial intelligence in drug combination therapy
1449 -- 1464Juan Xie, Anjun Ma, Anne Fennell, Qin Ma 0003, Jing Zhao. It is time to apply biclustering: a comprehensive review of biclustering applications in biological and biomedical data
1465 -- 1474Ming Hao, Stephen H. Bryant, Yanli Wang. Open-source chemogenomic data-driven algorithms for predicting drug-target interactions
1477 -- 1491Daniela Oliveira, Anila Sahar Butt, Armin Haller, Dietrich Rebholz-Schuhmann, Ratnesh Sahay. Where to search top-K biomedical ontologies?
1492 -- 1501Jue Yang, Hui Song, Kun Cao, Jialei Song, Jianjiang Zhou. Comprehensive analysis of Helicobacter pylori infection-associated diseases based on miRNA-mRNA interaction network
1502 -- 1512Hua Sun, Pora Kim, Peilin Jia, Aekyung Park, Han Liang, Zhongming Zhao. Distinct telomere length and molecular signatures in seminoma and non-seminoma of testicular germ cell tumor
1513 -- 1523António Cruz, Joel P. Arrais, Penousal Machado. Interactive and coordinated visualization approaches for biological data analysis
1524 -- 1541Zhuo Zhang, Hao Li, Shuai Jiang, Ruijiang Li, Wanying Li, Hebing Chen, Xiaochen Bo. A survey and evaluation of Web-based tools/databases for variant analysis of TCGA data
1542 -- 1559Damla Senol Cali, Jeremie S. Kim, Saugata Ghose, Can Alkan, Onur Mutlu. Nanopore sequencing technology and tools for genome assembly: computational analysis of the current state, bottlenecks and future directions
1560 -- 1567David Arndt, Ana Marcu, Yongjie Liang, David S. Wishart. PHAST, PHASTER and PHASTEST: Tools for finding prophage in bacterial genomes
1568 -- 1577Huansheng Cao, Qin Ma 0003, Xin Chen, Ying Xu 0001. DOOR: a prokaryotic operon database for genome analyses and functional inference
1576 -- 1582Paul Stothard, Jason R. Grant, Gary H. Van Domselaar. Visualizing and comparing circular genomes using the CGView family of tools
1583 -- 1589Shun H. Yip, Pak Chung Sham, Junwen Wang. Evaluation of tools for highly variable gene discovery from single-cell RNA-seq data
1590 -- 1603Gaoyang Li, Huansheng Cao, Ying Xu 0001. Structural and functional analyses of microbial metabolic networks reveal novel insights into genome-scale metabolic fluxes

Volume 20, Issue 3

745 -- 751Jing Feng, Yu Xiang, Siyu Xia, Huan Liu, Jun Wang, Fatma Muge Ozguc, Lijun Lei, Ruoshan Kong, Lixia Diao, Chunjiang He, Leng Han. CircView: a visualization and exploration tool for circular RNAs
752 -- 766Gonzalo Gómez-López, Joaquín Dopazo, Juan C. Cigudosa, Alfonso Valencia, Fátima Al-Shahrour. Precision medicine needs pioneering clinical bioinformaticians
767 -- 777Girolamo Giudice, Evangelia Petsalaki. Proteomics and phosphoproteomics in precision medicine: applications and challenges
778 -- 788Jochen Singer, Anja Irmisch, Hans-Joachim Ruscheweyh, Franziska Singer, Nora C. Toussaint, Mitchell P. Levesque, Daniel J. Stekhoven, Niko Beerenwinkel. Bioinformatics for precision oncology
789 -- 805Francesca Vitali, Qike Li, A. Grant Schissler, Joanne Berghout, Colleen Kenost, Yves A. Lussier. Developing a 'personalome' for precision medicine: emerging methods that compute interpretable effect sizes from single-subject transcriptomes
806 -- 824Anastasis Oulas, George Minadakis, Margarita Zachariou, Kleitos Sokratous, Marilena M. Bourdakou, George M. Spyrou. Systems Bioinformatics: increasing precision of computational diagnostics and therapeutics through network-based approaches
825 -- 841Nikolas Dovrolis, George Kolios, George M. Spyrou, Ioanna Maroulakou. Computational profiling of the gut-brain axis: microflora dysbiosis insights to neurological disorders
842 -- 856Jessica D. Tenenbaum, Krithika Bhuvaneshwar, Jane P. Gagliardi, Kate Fultz Hollis, Peilin Jia, Liang Ma, Radhakrishnan Nagarajan, Gopalkumar Rakesh, Vignesh Subbian, Shyam Visweswaran, Zhongming Zhao, Leon Rozenblit. Translational bioinformatics in mental health: open access data sources and computational biomarker discovery
857 -- 865Cedric Christian Laczny, Valentina Galata, Achim Plum, Andreas E. Posch, Andreas Keller. Assessing the heterogeneity of in silico plasmid predictions based on whole-genome-sequenced clinical isolates
866 -- 876Vasanthan Jayakumar, Yasubumi Sakakibara. Comprehensive evaluation of non-hybrid genome assembly tools for third-generation PacBio long-read sequence data
877 -- 886Fei Liu 0006, Monika Heiner, David R. Gilbert. Coloured Petri nets for multilevel, multiscale and multidimensional modelling of biological systems
887 -- 895Md Momin Al Aziz, Md. Nazmus Sadat, Dima Alhadidi, Shuang Wang 0002, Xiaoqian Jiang, Cheryl L. Brown, Noman Mohammed. Privacy-preserving techniques of genomic data - a survey
896 -- 917Xing Chen, Ya-Zhou Sun, Hui Liu, Lin Zhang 0015, Jian-qiang Li, Jia Meng. RNA methylation and diseases: experimental results, databases, Web servers and computational models
918 -- 930Michele Bortolomeazzi, Enrico Gaffo, Stefania Bortoluzzi. A survey of software tools for microRNA discovery and characterization using RNA-seq
931 -- 951Jiawei Wang, Bingjiao Yang, Yi An, Tatiana T. Marquez-Lago, André Leier, Jonathan Wilksch, Qingyang Hong, Yang Zhang 0010, Morihiro Hayashida, Tatsuya Akutsu, Geoffrey I. Webb, Richard A. Strugnell, Jiangning Song, Trevor Lithgow. Systematic analysis and prediction of type IV secreted effector proteins by machine learning approaches
952 -- 975Yuxin Lin, Fuliang Qian, Li Shen, Feifei Chen, Jiajia Chen, Bairong Shen. Computer-aided biomarker discovery for precision medicine: data resources, models and applications
976 -- 984Yun-Ru Chen, Hsuan-Cheng Huang, Chen-Ching Lin. Regulatory feedback loops bridge the human gene regulatory network and regulate carcinogenesis
985 -- 994Leili Shahriyari. Effect of normalization methods on the performance of supervised learning algorithms applied to HTSeq-FPKM-UQ data sets: 7SK RNA expression as a predictor of survival in patients with colon adenocarcinoma
995 -- 1003Boyang Li, Qiongshi Lu, Hongyu Zhao. An evaluation of noncoding genome annotation tools through enrichment analysis of 15 genome-wide association studies
1004 -- 1010Ágnes Osz, Lorinc Sándor Pongor, Danuta Szirmai, Balazs Györffy. A snapshot of 3649 Web-based services published between 1994 and 2017 shows a decrease in availability after 2 years
1011 -- 1020Tobias Fehlmann, Shashwat Sahay, Andreas Keller, Christina Backes. A review of databases predicting the effects of SNPs in miRNA genes or miRNA-binding sites
1021 -- 1031Hairong Wei. Construction of a hierarchical gene regulatory network centered around a transcription factor
1032 -- 1056Aitor Blanco-Míguez, Florentino Fdez-Riverola, Borja Sánchez, Anália Lourenço. Resources and tools for the high-throughput, multi-omic study of intestinal microbiota
1057 -- 1062Massimiliano Zanin, Ivan Chorbev, Blaz Stres, Egils Stalidzans, Julio Vera, Paolo Tieri, Filippo Castiglione, Derek Groen, Huiru Zheng, Jan Baumbach, Johannes A. Schmid, José Basilio, Peter Klimek, Natasa Debeljak, Damjana Rozman, Harald H. H. W. Schmidt. Community effort endorsing multiscale modelling, multiscale data science and multiscale computing for systems medicine

Volume 20, Issue 2

361 -- 369Vivienne Baillie Gerritsen, Patricia M. Palagi, Christine Durinx. Bioinformatics on a national scale: an example from Switzerland
370 -- 374Andreas Tauch, Arwa Al-Dilaimi. Bioinformatics in Germany: toward a national-level infrastructure
384 -- 389Maria Victoria Schneider, Philippa C. Griffin, Sonika Tyagi, Madison Flannery, Saravanan Dayalan, Simon Gladman, Nathan S. Watson-Haigh, Philipp E. Bayer, Michael Charleston, Ira Cooke, Rob Cook, Richard J. Edwards, David Edwards, Dominique Gorse, Malcolm J. McConville, David Powell, Marc R. Wilkins, Andrew Lonie. Establishing a distributed national research infrastructure providing bioinformatics support to life science researchers in Australia
390 -- 397Javier De Las Rivas, César Bonavides-Martínez, Francisco Jose Campos-Laborie. Bioinformatics in Latin America and SoIBio impact, a tale of spin-off and expansion around genomes and protein structures
398 -- 404Teresa K. Attwood, Sarah Blackford, Michelle D. Brazas, Angela Davies, Maria Victoria Schneider. A global perspective on evolving bioinformatics and data science training needs
405 -- 415Allegra Via, Teresa K. Attwood, Pedro L. Fernandes, Sarah L. Morgan, Maria Victoria Schneider, Patricia M. Palagi, Gabriella Rustici, Rochelle E. Tractenberg. A new pan-European Train-the-Trainer programme for bioinformatics: pilot results on feasibility, utility and sustainability of learning
416 -- 425Rochelle E. Tractenberg. Degrees of freedom analysis in educational research and decision-making: leveraging qualitative data to promote excellence in bioinformatics training and education
426 -- 435Guillaume Bernard, Cheong Xin Chan, Yao-ban Chan, Xin-Yi Chua, Yingnan Cong, James M. Hogan, Stefan R. Maetschke, Mark A. Ragan. Alignment-free inference of hierarchical and reticulate phylogenomic relationships
436 -- 447Maria Angela Diroma, Loredana Ciaccia, Graziano Pesole, Ernesto Picardi. Elucidating the editome: bioinformatics approaches for RNA editing detection
448 -- 456Shiwei Ma, Qi Song, Huan Tao, Andrew Harrison, Shaobo Wang, Wei Liu 0072, Shoukai Lin, Ziding Zhang, Yufang Ai, Huaqin He. Prediction of protein-protein interactions between fungus (Magnaporthe grisea) and rice (Oryza sativa L.)
457 -- 462Nicholas P. Tatonetti. Translational medicine in the Age of Big Data
463 -- 470Pablo Mier, Miguel A. Andrade-Navarro. Toward completion of the Earth's proteome: an update a decade later
471 -- 481Gabriela Alejandra Merino, Ana Conesa, Elmer Andrés Fernández. A benchmarking of workflows for detecting differential splicing and differential expression at isoform level in human RNA-seq studies
482 -- 491Xiangyu Li, Hao Cai, Xianlong Wang, Lu Ao, You Guo, Jun He, Yunyan Gu, Lishuang Qi, Qingzhou Guan, Xu Lin, Zheng Guo 0002. A rank-based algorithm of differential expression analysis for small cell line data with statistical control
492 -- 503Frauke Degenhardt, Stephan Seifert, Silke Szymczak. Evaluation of variable selection methods for random forests and omics data sets
504 -- 514Emmanuel S. Adabor, George K. Acquaah-Mensah. Machine learning approaches to decipher hormone and HER2 receptor status phenotypes in breast cancer
515 -- 539Xing Chen, Di Xie, Qi Zhao, Zhu-Hong You. MicroRNAs and complex diseases: from experimental results to computational models
540 -- 550Celia W. G. van Gelder, Rob W. W. Hooft, Merlijn N. van Rijswijk, Linda van den Berg, Ruben G. Kok, Marcel J. T. Reinders, Barend Mons, Jaap Heringa. Bioinformatics in the Netherlands: the value of a nationwide community
540 -- 550Maxwell Lewis Neal, Matthias König, David P. Nickerson, Goksel Misirli, Reza Kalbasi, Andreas Dräger, Koray Atalag, Vijayalakshmi Chelliah, Michael T. Cooling, Daniel L. Cook, Sharon M. Crook, Miguel de Alba, Samuel H. Friedman, Alan Garny, John H. Gennari, Padraig Gleeson, Martin Golebiewski, Michael Hucka, Nick S. Juty, Chris J. Myers, Brett G. Olivier, Herbert M. Sauro, Martin Scharm, Jacky L. Snoep, Vasundra Touré, Anil Wipat, Olaf Wolkenhauer, Dagmar Waltemath. Harmonizing semantic annotations for computational models in biology
551 -- 564Ivan V. Antonov, Evgeny Mazurov, Mark Borodovsky, Yulia A. Medvedeva. Prediction of lncRNAs and their interactions with nucleic acids: benchmarking bioinformatics tools
565 -- 571Armin Scheben, Chon-Kit Kenneth Chan, Locedie Mansueto, Ramil Mauleon, Pierre Larmande, Nickolai Alexandrov, Rod A. Wing, Kenneth L. McNally, Hadi Quesneville, David Edwards. Progress in single-access information systems for wheat and rice crop improvement
572 -- 584Lan Zhao, Victor H. F. Lee, Michael K. Ng, Hong Yan 0001, Maarten F. Bijlsma. Molecular subtyping of cancer: current status and moving toward clinical applications
585 -- 597Hao Feng, Peng Jin, Hao Wu. Disease prediction by cell-free DNA methylation
598 -- 608Meng Zhou, Hengqiang Zhao, Xinyu Wang, Jie Sun, Jianzhong Su. Analysis of long noncoding RNAs highlights region-specific altered expression patterns and diagnostic roles in Alzheimer's disease
609 -- 623Mansoor Saqi, Artem Lysenko, Yike Guo, Tatsuhiko Tsunoda, Charles Auffray. Navigating the disease landscape: knowledge representations for contextualizing molecular signatures
624 -- 637MengYun Wu, Shuangge Ma. Robust genetic interaction analysis
638 -- 658Jiangning Song, Yanan Wang, Fuyi Li, Tatsuya Akutsu, Neil D. Rawlings, Geoffrey I. Webb, Kuo-Chen Chou. iProt-Sub: a comprehensive package for accurately mapping and predicting protease-specific substrates and cleavage sites
659 -- 670Marek Ostaszewski, Stephan Gebel, Inna Kuperstein, Alexander Mazein, Andrei Zinovyev, Ugur Dogrusoz, Jan Hasenauer, Ronan M. T. Fleming, Nicolas Le Novère, Piotr Gawron, Thomas S. Ligon, Anna Niarakis, David P. Nickerson, Daniel Weindl, Rudi Balling, Emmanuel Barillot, Charles Auffray, Reinhard Schneider 0002. Community-driven roadmap for integrated disease maps
671 -- 681Bettina M. Pucher, Oana A. Zeleznik, Gerhard G. Thallinger. Comparison and evaluation of integrative methods for the analysis of multilevel omics data: a study based on simulated and experimental cancer data
682 -- 689Tatianne da Costa Negri, Wonder Alexandre Luz Alves, Pedro Henrique Bugatti, Priscila Tiemi Maeda Saito, Douglas Silva Domingues, Alexandre Rossi Paschoal. Pattern recognition analysis on long noncoding RNAs: a tool for prediction in plants
690 -- 700Emile R. Chimusa, Shareefa Dalvie, Collet Dandara, Ambroise Wonkam, Gaston K. Mazandu. Post genome-wide association analysis: dissecting computational pathway/network-based approaches
701 -- 716L. Cristobal Monraz Gomez, Maria Kondratova, Jean-Marie Ravel, Emmanuel Barillot, Andrei Zinovyev, Inna Kuperstein. Application of Atlas of Cancer Signalling Network in preclinical studies
717 -- 731Farnaz Barneh, Mehdi Mirzaie, Payman Nickchi, Tuan Zea Tan, Jean-Paul Thiery, Mehran Piran, Mona Salimi, Fatemeh Goshadrou, Amir R. Aref, Mohieddin Jafari. Integrated use of bioinformatic resources reveals that co-targeting of histone deacetylases, IKBK and SRC inhibits epithelial-mesenchymal transition in cancer
732 -- 734Feng Gao 0001. Recent developments of software and database in microbial genomics and functional genomics
735 -- 736Maria Victoria Schneider. Bioinformatics: scalability, capabilities and training in the data-driven era

Volume 20, Issue 1

1 -- 14Chia-Wei Chen, Hsin-Chou Yang. OPATs: Omnibus P-value association tests
15 -- 25Gennady G. Fedonin, Yury S. Fantin, Alexander V. Favorov, German A. Shipulin, Alexey D. Neverov. VirGenA: a reference-based assembler for variable viral genomes
26 -- 32Shan-Shan Dong, Yan Guo, Shi Yao, Yi-Xiao Chen, Mo-Nan He, Yu-Jie Zhang, Xiao-Feng Chen, Jia-Bin Chen, Tie-Lin Yang. Integrating regulatory features data for prediction of functional disease-associated SNPs
33 -- 46Ik-Soo Huh, Xin Wu, Taesung Park, Soojin V. Yi. Detecting differential DNA methylation from sequencing of bisulfite converted DNA of diverse species
47 -- 57Ya Wang, Andrew E. Teschendorff, Martin Widschwendter, Shuang Wang. Accounting for differential variability in detecting differentially methylated regions
58 -- 65Jiazhen Ye, Lin Wang, Shuzhang Li, Qinran Zhang, Qinglei Zhang, Wenhao Tang, Kai Wang, Kun Song, Gaurav Sablok, Xiaoyong Sun, Hongwei Zhao. AtCircDB: a tissue-specific database for Arabidopsis circular RNAs
66 -- 76Yongsheng Li, Caiqin Huo, Tao Pan, Lili Li, Xiyun Jin, Xiaoyu Lin, Juan Chen, Jinwen Zhang, Zheng Guo, Juan Xu, Xia Li. Systematic review regulatory principles of non-coding RNAs in cardiovascular diseases
77 -- 88Adrian Baez-Ortega, Kevin Gori. Computational approaches for discovery of mutational signatures in cancer
89 -- 101Duanchen Sun, Xian-Wen Ren, Eszter Ari, Tamás Korcsmáros, Peter Csermely, Ling-Yun Wu. Discovering cooperative biomarkers for heterogeneous complex disease diagnoses
102 -- 109Li Yao, Heming Wang, Yuanyuan Song, Zhen Dai, Hao Yu, Ming Yin, Dongxu Wang, Xin Yang, Jinlin Wang, Tiedong Wang, Nan Cao, Jimin Zhu, Xizhong Shen, Guangqi Song, Yicheng Zhao. Large-scale prediction of ADAR-mediated effective human A-to-I RNA editing
110 -- 129Cong Zeng, Lingyun Zou. An account of in silico identification tools of secreted effector proteins in bacteria and future challenges
130 -- 143Ajanthah Sangaralingam, Abu Z. Dayem Ullah, Jacek Marzec, Emanuela Gadaleta, Ai Nagano, Helen Ross-Adams, Jun Wang, Nicholas R. Lemoine, Claude Chelala. 'Multi-omic' data analysis using O-miner
144 -- 155Hongwei Wang, Yan Wang, Zhi Xie. Computational resources for ribosome profiling: from database to Web server and software
156 -- 167Xiaoming Wang, Carolyn Williams, Zhen Hua Liu, Joe Croghan. Big data management challenges in health research - a literature review
168 -- 177Qian Yang, Shuyuan Wang, Enyu Dai, Shunheng Zhou, Dianming Liu, Haizhou Liu, Qianqian Meng, Bin Jiang, Wei Jiang. Pathway enrichment analysis approach based on topological structure and updated annotation of pathway
178 -- 189Xue Li, Xinlei Wang 0001, Guanghua Xiao. A comparative study of rank aggregation methods for partial and top ranked lists in genomic applications
190 -- 202Emir Muñoz, Vít Novácek, Pierre-Yves Vandenbussche. Facilitating prediction of adverse drug reactions by using knowledge graphs and multi-label learning models
203 -- 209Liang Cheng 0006, Haixiu Yang, Hengqiang Zhao, Xiaoya Pei, Hongbo Shi, Jie Sun, Yunpeng Zhang, Zhenzhen Wang, Meng Zhou. MetSigDis: a manually curated resource for the metabolic signatures of diseases
210 -- 221Stijn Hawinkel, Federico Mattiello, Luc Bijnens, Olivier Thas. A broken promise: microbiome differential abundance methods do not control the false discovery rate
222 -- 234Saira Afzal, Irene Gil-Farina, Richard Gabriel, Shahzad Ahmad, Christof von Kalle, Manfred Schmidt, Raffaele Fronza. Systematic comparative study of computational methods for T-cell receptor sequencing data analysis
235 -- 244Somali Chaterji, Jinkyu Koo, Ninghui Li, Folker Meyer, Ananth Grama, Saurabh Bagchi. Federation in genomics pipelines: techniques and challenges
245 -- 253Mohamad Saad, Ellen M. Wijsman. Association score testing for rare variants and binary traits in family data with shared controls
254 -- 266Yulan Deng, Shangyi Luo, Chunyu Deng, Tao Luo, Wenkang Yin, Hongyi Zhang, Yong Zhang, Xinxin Zhang, Yujia Lan, Yanyan Ping, Yun Xiao 0001, Xia Li 0004. Identifying mutual exclusivity across cancer genomes: computational approaches to discover genetic interaction and reveal tumor vulnerability
267 -- 273Reuben J. Pengelly, Alejandra Vergara-Lope, Dareen Alyousfi, M. Reza Jabalameli, Andrew Collins. Understanding the disease genome: gene essentiality and the interplay of selection, recombination and mutation
274 -- 287Shiping Yang, Hong Li, Huaqin He, Yuan Zhou, Ziding Zhang. Critical assessment and performance improvement of plant-pathogen protein-protein interaction prediction methods
288 -- 298Daniel Spies, Peter F. Renz, Tobias A. Beyer, Constance Ciaudo. Comparative analysis of differential gene expression tools for RNA sequencing time course data
299 -- 316Elizabeth Sam, Prashanth Athri. Web-based drug repurposing tools: a survey
317 -- 329Yipeng Song, Johan A. Westerhuis, Nanne Aben, Magali Michaut, Lodewyk F. A. Wessels, Age K. Smilde. Principal component analysis of binary genomics data
330 -- 346Yumeng Liu, Xiaolong Wang, Bin Liu. A comprehensive review and comparison of existing computational methods for intrinsically disordered protein and region prediction
347 -- 355Wilson Wen Bin Goh, Limsoon Wong. Advanced bioinformatics methods for practical applications in proteomics
356 -- 359Cristina Marino Buslje, Alexander Miguel Monzon, Diego Javier Zea, María Silvina Fornasari, Gustavo D. Parisi. On the dynamical incompleteness of the Protein Data Bank