Journal: Briefings in Bioinformatics

Volume 21, Issue 6

1857 -- 1874Xiaoxia Ma, Yijun Meng, Pu Wang, Zhonghai Tang, Huizhong Wang, Tian Xie. Bioinformatics-assisted, integrated omics studies on medicinal plants
1875 -- 1885Ehsan Ullah, Mona Yosafshahi, Soha Hassoun. Towards scaling elementary flux mode computation
1886 -- 1903Hongcheng Yao, Qian Liang, Xinyi Qian, Junwen Wang, Pak Chung Sham, Mulin Jun Li. Methods and resources to access mutation-dependent effects on cancer drug treatment
1904 -- 1919Riccardo De Bin, Anne-Laure Boulesteix, Axel Benner, Natalia Becker, Willi Sauerbrei. Combining clinical and molecular data in regression prediction models: insights from a simulation study
1920 -- 1936Anita Sathyanarayanan, Rohit Gupta, Erik W. Thompson, Dale R. Nyholt, Denis C. Bauer, Shivashankar H. Nagaraj. A comparative study of multi-omics integration tools for cancer driver gene identification and tumour subtyping
1937 -- 1953Jussi Paananen, Vittorio Fortino. An omics perspective on drug target discovery platforms
1954 -- 1970Yiwen Wang, Kim-Anh Lê Cao. Managing batch effects in microbiome data
1971 -- 1986Matteo Chiara, Federico Zambelli, Ernesto Picardi, David Stephen Horner, Graziano Pesole. Critical assessment of bioinformatics methods for the characterization of pathological repeat expansions with single-molecule sequencing data
1987 -- 1998Sebastiano Di Bella, Alessandro La Ferlita, Giovanni Carapezza, Salvatore Alaimo, Antonella Isacchi, Alfredo Ferro, Alfredo Pulvirenti, Roberta Bosotti. A benchmarking of pipelines for detecting ncRNAs from RNA-Seq data
1999 -- 2010Fabian Kern, Christina Backes, Pascal Hirsch, Tobias Fehlmann, Martin Hart, Eckart Meese, Andreas Keller. What's the target: understanding two decades of in silico microRNA-target prediction
2011 -- 2030Morgane Pierre-Jean, Jean-Francois Deleuze, Edith Le Floch, Florence Mauger. Clustering and variable selection evaluation of 13 unsupervised methods for multi-omics data integration
2031 -- 2051Bohdan B. Khomtchouk, Diem-Trang T. Tran, Kasra A. Vand, Matthew Might, Or Gozani, Themistocles L. Assimes. Cardioinformatics: the nexus of bioinformatics and precision cardiology
2052 -- 2065Arfa Mehmood, Asta Laiho, Mikko S. Venäläinen, Aidan J. McGlinchey, Ning Wang, Laura L. Elo. Systematic evaluation of differential splicing tools for RNA-seq studies
2066 -- 2083Yu-Chiao Chiu, Hung-I Harry Chen, Aparna Gorthi, Milad Mostavi, SiYuan Zheng, Yufei Huang, Yidong Chen. Deep learning of pharmacogenomics resources: moving towards precision oncology
2084 -- 2098Jun Sun, Qianqian Shi, Xi Chen, Rong Liu. Decoding the similarities and specific differences between latent and active tuberculosis infections based on consistently differential expression networks
2099 -- 2111Xuan Lin, Zhe Quan, Zhi-jie Wang, Huang Huang, Xiangxiang Zeng. A novel molecular representation with BiGRU neural networks for learning atom
2112 -- 2125Süleyman Selim Çinaroglu, Emel Timuçin. Comprehensive evaluation of the MM-GBSA method on bromodomain-inhibitor sets
2126 -- 2132Xiao Ding, Xuye Yuan, Longfei Mao, Aiping Wu, Taijiao Jiang. FluReassort: a database for the study of genomic reassortments among influenza viruses
2133 -- 2141Chen-Chen Li, Bin Liu. MotifCNN-fold: protein fold recognition based on fold-specific features extracted by motif-based convolutional neural networks
2142 -- 2152Qingxia Yang, Jiajun Hong, Yi Li, Weiwei Xue, Song Li, Hui Yang, Feng Zhu 0004. A novel bioinformatics approach to identify the consistently well-performing normalization strategy for current metabolomic studies
2153 -- 2166Yanjun Xu, Tan Wu, Feng Li, Qun Dong, Jingwen Wang, Desi Shang, Yingqi Xu, Chunlong Zhang, Yiying Dou, Congxue Hu, Haixiu Yang, Xuan Zheng, Yunpeng Zhang, Lihua Wang 0002, Xia Li 0004. Identification and comprehensive characterization of lncRNAs with copy number variations and their driving transcriptional perturbed subpathways reveal functional significance for cancer
2167 -- 2174Qun Dong, Feng Li, Yanjun Xu, Jing Xiao, Yingqi Xu, Desi Shang, Chunlong Zhang, Haixiu Yang, Zihan Tian, Kai Mi 0003, Xia Li 0004, Yunpeng Zhang. RNAactDrug: a comprehensive database of RNAs associated with drug sensitivity from multi-omics data
2175 -- 2184Yao Lv, Sheng-Yan Lin, Fei-Fei Hu, Zheng Ye, Qiong Zhang, Yan Wang, An-Yuan Guo. Landscape of cancer diagnostic biomarkers from specifically expressed genes
2185 -- 2193Bin Liu, Yulin Zhu, Ke Yan 0003. Fold-LTR-TCP: protein fold recognition based on triadic closure principle
2194 -- 2205Kequan Lin, Lu Li, Yifei Dai, Huili Wang, Shuaishuai Teng, Xilinqiqige Bao, Zhi John Lu, Dong Wang. A comprehensive evaluation of connectivity methods for L1000 data
2206 -- 2218Jing-Fang Yang, Fan Wang, Yu Zong Chen, Ge-Fei Hao, Guangfu Yang. LARMD: integration of bioinformatic resources to profile ligand-driven protein dynamics with a case on the activation of estrogen receptor
2219 -- 2238Ming-Siang Huang, Po-Ting Lai, Pei-Yen Lin, Yu-Ting You, Richard Tzong-Han Tsai, Wen-Lian Hsu. Biomedical named entity recognition and linking datasets: survey and our recent development

Volume 21, Issue 5

1495 -- 1508Antonio Mora. Gene set analysis methods for the functional interpretation of non-mRNA data - Genomic range and ncRNA data
1509 -- 1522Akila Katuwawala, Christopher J. Oldfield, Lukasz A. Kurgan. Accuracy of protein-level disorder predictions
1523 -- 1530Stefania Salvatore, Knut Dagestad Rand, Ivar Grytten, Egil Ferkingstad, Diana Domanska, Lars Holden, Marius Gheorghe, Anthony Mathelier, Ingrid K. Glad, Geir Kjetil Sandve. Beware the Jaccard: the choice of similarity measure is important and non-trivial in genomic colocalisation analysis
1531 -- 1548Zhourun Wu, Qing Liao 0001, Bin Liu 0014. A comprehensive review and evaluation of computational methods for identifying protein complexes from protein-protein interaction networks
1549 -- 1567Richard A. Norman, Francesco Ambrosetti, Alexandre M. J. J. Bonvin, Lucy J. Colwell, Sebastian Kelm, Sandeep Kumar, Konrad Krawczyk. Computational approaches to therapeutic antibody design: established methods and emerging trends
1568 -- 1580Hui Yang, Wuritu Yang, Fu-Ying Dao, Hao Lv, Hui Ding, Wei Chen, Hao Lin. A comparison and assessment of computational method for identifying recombination hotspots in Saccharomyces cerevisiae
1581 -- 1595Xinlei Zhao, Shuang Wu, Nan Fang, Xiao Sun, Jue Fan. Evaluation of single-cell classifiers for single-cell RNA sequencing data sets
1596 -- 1608Robert Rentzsch, Carlus Deneke, Andreas Nitsche, Bernhard Y. Renard. Predicting bacterial virulence factors - evaluation of machine learning and negative data strategies
1609 -- 1627Tianlin Zhang, Jiaxu Leng, Ying Liu 0039. Deep learning for drug-drug interaction extraction from the literature: a review
1628 -- 1640Yinan Shen, Yijie Ding, Jijun Tang, Quan Zou 0001, Fei Guo. Critical evaluation of web-based prediction tools for human protein subcellular localization
1641 -- 1662Weifeng Guo, Shaowu Zhang 0001, Tao Zeng, Tatsuya Akutsu, Luonan Chen. Network control principles for identifying personalized driver genes in cancer
1663 -- 1675Francis E. Agamah, Gaston K. Mazandu, Radia Hassan, Christian D. Bope, Nicholas E. Thomford, Anita Ghansah, Emile R. Chimusa. Computational/in silico methods in drug target and lead prediction
1676 -- 1696Zhen Chen 0009, Pei Zhao, Fuyi Li, Yanan Wang, Alexander Ian Smith, Geoffrey I. Webb, Tatsuya Akutsu, Abdelkader Baggag, Halima Bensmail, Jiangning Song. Comprehensive review and assessment of computational methods for predicting RNA post-transcriptional modification sites from RNA sequences
1697 -- 1705Jon C. Ison, Hervé Ménager, Bryan Brancotte, Erik Jaaniso, Ahto Salumets, Tomás Racek, Anna-Lena Lamprecht, Magnus Palmblad, Matús Kalas, Piotr Chmura, John M. Hancock, Veit Schwämmle, Hans-Ioan Ienasescu. Community curation of bioinformatics software and data resources
1706 -- 1716Yanfang Zhang, Xiujia Yang, Yanxia Zhang, Yan Zhang, Minhui Wang, Jin Xia Ou, Yan Zhu, Huikun Zeng, JiaQi Wu, Chunhong Lan, Hong-Wei Zhou, Wei Yang, Zhenhai Zhang. Tools for fundamental analysis functions of TCR repertoires: a systematic comparison
1717 -- 1732Xu Chi, Maureen A. Sartor, Sanghoon Lee, Meenakshi Anurag, Snehal Patil, Pelle Hall, Matthew Wexler, Xiao-Song Wang. Universal concept signature analysis: genome-wide quantification of new biological and pathological functions of genes and pathways
1733 -- 1741Bin Liu, Chen-Chen Li, Ke Yan 0003. DeepSVM-fold: protein fold recognition by combining support vector machines and pairwise sequence similarity scores generated by deep learning networks
1742 -- 1755Siqi Bao, Hengqiang Zhao, Jian Yuan, Dandan Fan, Zicheng Zhang, Jianzhong Su, Meng Zhou 0003. Computational identification of mutator-derived lncRNA signatures of genome instability for improving the clinical outcome of cancers: a case study in breast cancer
1756 -- 1765Bo Sun, Liang Chen. Quantile regression for challenging cases of eQTL mapping
1766 -- 1775Marco Cacciabue, Anabella Currá, Elisa Carrillo, Guido König, María Inés Gismondi. A beginner's guide for FMDV quasispecies analysis: sub-consensus variant detection and haplotype reconstruction using next-generation sequencing
1776 -- 1786Bin Tang, Bin Li, Liang-Di Gao, Na He, Xiao-Rong Liu, Yue-Sheng Long, Yang Zeng, Yong-Hong Yi, Tao Su, Wei-Ping Liao. Optimization of in silico tools for predicting genetic variants: individualizing for genes with molecular sub-regional stratification
1787 -- 1797Chenyang Hong, Kevin Y. Yip. Flexible k-mers with variable-length indels for identifying binding sequences of protein dimers
1798 -- 1805Kai Yu, Qingfeng Zhang, Zekun Liu, Yimeng Du, Xinjiao Gao, Qi Zhao, Han Cheng, Xiaoxing Li, Zexian Liu. Deep learning based prediction of reversible HAT/HDAC-specific lysine acetylation
1806 -- 1817Wei-Yang Bai, Xiao-Wei Zhu, Pei-Kuan Cong, Xue-Jun Zhang, J. Brent Richards, Hou-Feng Zheng. Genotype imputation and reference panel: a systematic evaluation on haplotype size and diversity
1818 -- 1824Qi Zhao, Yu Sun, Zekun Liu, Hongwan Zhang, Xingyang Li, Kaiyu Zhu, Zexian Liu, Jian Ren 0002, Zhixiang Zuo. CrossICC: iterative consensus clustering of cross-platform gene expression data without adjusting batch effect
1825 -- 1836Jiajun Hong, Yongchao Luo, Minjie Mou, Jianbo Fu, Yang Zhang, Weiwei Xue, Tian Xie, Lin Tao, Yan Lou, Feng Zhu 0004. Convolutional neural network-based annotation of bacterial type IV secretion system effectors with enhanced accuracy and reduced false discovery
1837 -- 1845Ephifania Geza, Nicola J. Mulder, Emile R. Chimusa, Gaston K. Mazandu. FRANC: a unified framework for multi-way local ancestry deconvolution with high density SNP data
1846 -- 1855Bing Rao, Chen Zhou, Guoying Zhang, Ran Su, Leyi Wei. ACPred-Fuse: fusing multi-view information improves the prediction of anticancer peptides
1856 -- 0Jian Zhang 0020, Zhiqiang Ma, Lukasz A. Kurgan. Corrigendum to: Comprehensive review and empirical analysis of hallmarks of DNA-, RNA- and protein-binding residues in protein chains

Volume 21, Issue 4

1119 -- 1135Shutao Mei, Fuyi Li, André Leier, Tatiana T. Marquez-Lago, Kailin Giam, Nathan P. Croft, Tatsuya Akutsu, A. Ian Smith, Jian Li, Jamie Rossjohn, Anthony W. Purcell, Jiangning Song. A comprehensive review and performance evaluation of bioinformatics tools for HLA class I peptide-binding prediction
1136 -- 1150Vincent Briane, Myriam Vimond, Charles Kervrann. An overview of diffusion models for intracellular dynamics analysis
1151 -- 1163Asmita Gupta, Manju Bansal. RNA-mediated translation regulation in viral genomes: computational advances in the recognition of sequences and structures
1164 -- 1181Leandro Lima, Camille Marchet, Ségolène Caboche, Corinne Da Silva, Benjamin Istace, Jean-Marc Aury, Hélène Touzet, Rayan Chikhi. Comparative assessment of long-read error correction software applied to Nanopore RNA-sequencing data
1182 -- 1195Andrew C. Liu, Krishna Patel, Ramya Dhatri Vunikili, Kipp W. Johnson, Fahad Abdu, Shivani Kamath Belman, Benjamin S. Glicksberg, Pratyush Tandale, Roberto Fontanez, Oommen K. Mathew, Andrew Kasarskis, Priyabrata Mukherjee, Lakshminarayanan Subramanian, Joel T. Dudley, Khader Shameer. Sepsis in the era of data-driven medicine: personalizing risks, diagnoses, treatments and prognoses
1196 -- 1208Ren Qi, Anjun Ma, Qin Ma, Quan Zou 0001. Clustering and classification methods for single-cell RNA-sequencing data
1209 -- 1223Raphael Petegrosso, Zhuliu Li, Rui Kuang. Machine learning and statistical methods for clustering single-cell RNA-sequencing data
1224 -- 1237Dimitri Guala, Christoph Ogris, Nikola Müller, Erik L. L. Sonnhammer. Genome-wide functional association networks: background, data & state-of-the-art resources
1238 -- 1248Fu Chen, Le Yuan, Shaozhen Ding, Yu Tian, Qian-Nan Hu. Data-driven rational biosynthesis design: from molecules to cell factories
1249 -- 1260David Hoksza, Piotr Gawron, Marek Ostaszewski, Jan Hasenauer, Reinhard Schneider 0002. Closing the gap between formats for storing layout information in systems biology
1261 -- 1276Moliang Chen, Guoli Ji, Hongjuan Fu, Qianmin Lin, Congting Ye, Wenbin Ye 0002, Yaru Su, Xiaohui Wu. A survey on identification and quantification of alternative polyadenylation sites from RNA-seq data
1277 -- 1284Sean D. McCabe, Dan-Yu Lin, Michael I Love. Consistency and overfitting of multi-omics methods on experimental data
1285 -- 1292Jianwen Fang. A critical review of five machine learning-based algorithms for predicting protein stability changes upon mutation
1293 -- 1301Hewei Zheng, Xueying Zhao, Hong Wang, Yu Ding, Xiaoyan Lu, Guosi Zhang, Jiaxin Yang, Lianzong Wang, Haotian Zhang, Yu Bai, Jing Li, Jingqi Wu, Yongshuai Jiang, Liangde Xu. Location deviations of DNA functional elements affected SNP mapping in the published databases and references
1302 -- 1312Mitra Ebrahimpoor, Pietro Spitali, Kristina M. Hettne, Roula Tsonaka, Jelle J. Goeman. Simultaneous Enrichment Analysis of all Possible Gene-sets: Unifying Self-Contained and Competitive Methods
1313 -- 1326Juan Cui, Jiang Shu. Circulating microRNA trafficking and regulation: computational principles and practice
1327 -- 1346Pingjian Ding, Wenjue Ouyang, Jiawei Luo, Chee-Keong Kwoh 0001. Heterogeneous information network and its application to human health and disease
1347 -- 1355Chaodong Zhang, Yingjiao Ju, Na Tang, Yun Li, Gang Zhang, Yuqin Song, Hailing Fang, Liang Yang, Jie Feng. Systematic analysis of supervised machine learning as an effective approach to predicate β-lactam resistance phenotype in Streptococcus pneumoniae
1356 -- 1367Hang Wei, Bin Liu. iCircDA-MF: identification of circRNA-disease associations based on matrix factorization
1368 -- 1377Dan Wang, Hai Xiang, Chao Ning, Hao Liu, Jian-feng Liu, Xingbo Zhao. Mitochondrial DNA enrichment reduced NUMT contamination in porcine NGS analyses
1378 -- 1390Jing Tang, Yunxia Wang, Jianbo Fu, Ying Zhou, Yongchao Luo, Ying Zhang, Bo Li, Qingxia Yang, Weiwei Xue, Yan Lou, Yunqing Qiu, Feng Zhu 0004. A critical assessment of the feature selection methods used for biomarker discovery in current metaproteomics studies
1391 -- 1396Meik Kunz, Beat Wolf, Maximilian Fuchs, Jan Christoph, Ke Xiao, Thomas Thum, David Atlan, Hans-Ulrich Prokosch, Thomas Dandekar. A comprehensive method protocol for annotation and integrated functional understanding of lncRNAs
1397 -- 1410Hebing Chen, Zhuo Zhang, Shuai Jiang, Ruijiang Li, Wanying Li, Chenghui Zhao, Hao Hong, Xin Huang, Hao Li 0035, Xiaochen Bo. New insights on human essential genes based on integrated analysis and the construction of the HEGIAP web-based platform
1411 -- 1424Meng Li, Jianmei Zhao, Xuecang Li, Yang Chen, Chenchen Feng, Fengcui Qian, Yuejuan Liu, Jian Zhang, Jianzhong He, Bo Ai, Ziyu Ning, Wei Liu, Xuefeng Bai, Xiaole Han, Zhiyong Wu, Xiue Xu, Zhidong Tang, Qi Pan, Liyan Xu, Chunquan Li, Qiuyu Wang, Enmin Li. HiFreSP: A novel high-frequency sub-pathway mining approach to identify robust prognostic gene signatures
1425 -- 1436Xiangxiang Zeng, Yue Zhong, Wei Lin, Quan Zou 0001. Predicting disease-associated circular RNAs using deep forests combined with positive-unlabeled learning methods
1437 -- 1447Jiajun Hong, Yongchao Luo, Yang Zhang, Junbiao Ying, Weiwei Xue, Tian Xie, Lin Tao, Feng Zhu 0004. Protein functional annotation of simultaneously improved stability, accuracy and false discovery rate achieved by a sequence-based deep learning
1448 -- 1454Yuli Gao, Guohui Chuai, Weichuan Yu, Shen Qu, Qi Liu. Data imbalance in CRISPR off-target prediction
1455 -- 1464JunCai Pu, Yue Yu, Yiyun Liu, Lu Tian, Siwen Gui, Xiaogang Zhong, Chu Fan, Shaohua Xu, Xuemian Song, Lanxiang Liu, Lining Yang, Peng Zheng, Jianjun Chen, Ke Cheng, Chanjuan Zhou, Haiyang Wang, Peng Xie. MENDA: a comprehensive curated resource of metabolic characterization in depression
1465 -- 1478Aimin Li, Peilin Jia, Saurav Mallik, Rong Fei, Hiroki Yoshioka, Akiko Suzuki, Junichi Iwata, Zhongming Zhao. Critical microRNAs and regulatory motifs in cleft palate identified by a conserved miRNA-TF-gene network approach in humans and mice
1479 -- 1486Jie Ping, Olufunmilola Oyebamiji, Hui Yu, Scott Ness, Jeremy Chien, Fei Ye, Huining Kang, David C. Samuels, Sergey Ivanov, Danqian Chen, Ying-Yong Zhao, Yan Guo. MutEx: a multifaceted gateway for exploring integrative pan-cancer genomic data
1487 -- 1494José A. Ferreira, Susana Fuentes. Some comments on certain statistical aspects of the study of the microbiome

Volume 21, Issue 3

753 -- 761Regina Brinster, Dominique Scherer, Justo Lorenzo Bermejo. Optimal selection of genetic variants for adjustment of population stratification in European association studies
762 -- 776Yu Ding, Hong Wang, Hewei Zheng, Lianzong Wang, Guosi Zhang, Jiaxin Yang, Xiaoyan Lu, Yu Bai, Haotian Zhang, Jing Li, Wenyan Gao, Fukun Chen, Shui Hu, Jingqi Wu, Liangde Xu. Evaluation of drug efficacy based on the spatial position comparison of drug-target interaction centers
777 -- 790Ziye Wang, Ying Wang, Jed A. Fuhrman, Fengzhu Sun, Shanfeng Zhu. Assessment of metagenomic assemblers based on hybrid reads of real and simulated metagenomic sequences
791 -- 802Neann Mathai, Ya Chen, Johannes Kirchmair. Validation strategies for target prediction methods
803 -- 814Fabio Fabris, Daniel Palmer, João Pedro de Magalhães, Alex Alves Freitas. Comparing enrichment analysis and machine learning for identifying gene properties that discriminate between gene classes
815 -- 835Zhongjie Liang, Gennady M. Verkhivker, Guang Hu. Integration of network models and evolutionary analysis into high-throughput modeling of protein dynamics and allosteric regulation: theory, tools and applications
836 -- 850Edwin Yu-Kiu Ho, Qin Cao, Meng-Ting Gu, Ricky Wai-Lun Chan, Qiong Wu, Mark Gerstein, Kevin Y. Yip. Shaping the nebulous enhancer in the era of high-throughput assays and genome editing
851 -- 862Charalampos Papachristou, Swati Biswas. Comparison of haplotype-based tests for detecting gene-environment interactions with rare variants
863 -- 875Jianjian Wang, Yuze Cao, Xiaoyu Lu, Tianfeng Wang, Shuang Li, Xiaotong Kong, Chunrui Bo, Jie Li, Xiaolong Wang, Heping Ma, Lei Li, Huixue Zhang, Shangwei Ning, Lihua Wang. MicroRNAs and nervous system diseases: network insights and computational challenges
876 -- 884Ansuman Chattopadhyay, Carrie L. Iwema, Barbara A Epstein, Adrian V. Lee, Arthur S. Levine. Molecular Biology Information Service: an innovative medical library-based bioinformatics support service for biomedical researchers
885 -- 905Saman Zeeshan, Ruoyun Xiong, Bruce T. Liang, Zeeshan Ahmed. 100 Years of evolving gene-disease complexities and scientific debutants
906 -- 918Jimmy Omony, Thomas Nussbaumer, Ruben Gutzat. DNA methylation analysis in plants: review of computational tools and future perspectives
919 -- 935Mengying Sun, Sendong Zhao, Coryandar Gilvary, Olivier Elemento, Jiayu Zhou, Fei Wang. Graph convolutional networks for computational drug development and discovery
936 -- 945Charles Vesteghem, Rasmus Froberg Brøndum, Mads Sønderkær, Mia Sommer, Alexander Schmitz, Julie Støve Bødker, Karen Dybkær, Tarec Christoffer El-Galaly, Martin Bøgsted. Implementing the FAIR Data Principles in precision oncology: review of supporting initiatives
946 -- 956Zijie Shen, Yuan Lin, Quan Zou 0001. Transcription factors-DNA interactions in rice: identification and verification
957 -- 969Feng Li, Tan Wu, Yanjun Xu, Qun Dong, Jing Xiao, Yingqi Xu, Qian Li, Chunlong Zhang, Jianxia Gao, Liqiu Liu, Xiaoxu Hu, Jian Huang, Xia Li, Yunpeng Zhang. A comprehensive overview of oncogenic pathways in human cancer
970 -- 981Na Cheng, Menglu Li, Le Zhao, Bo Zhang, Yuhua Yang, Chun-Hou Zheng, Junfeng Xia. Comparison and integration of computational methods for deleterious synonymous mutation prediction
982 -- 995Hao Lv, Zi-Mei Zhang, Shi-Hao Li, Jiu-Xin Tan, Wei Chen, Hao Lin. Evaluation of different computational methods on 5-methylcytosine sites identification
996 -- 1005Ran Su, Xinyi Liu, Guobao Xiao, Leyi Wei. Meta-GDBP: a high-level stacked regression model to improve anticancer drug response prediction
1006 -- 1015Yadong Yang, Tao Zhang, Rudan Xiao, Xiaopeng Hao, Huiqiang Zhang, Hongzhu Qu, Bingbing Xie, Tao Wang, Xiangdong Fang. Platform-independent approach for cancer detection from gene expression profiles of peripheral blood cells
1016 -- 1022Shiqiang Cheng, Bei Han, Miao Ding, Yan Wen, Mei Ma, Lu Zhang, Xin Qi, Bolun Cheng, Ping Li, Om Prakash Kafle, Xiao Liang, Li Liu, Yanan Du, Yan Zhao, Feng Zhang. Identifying psychiatric disorder-associated gut microbiota using microbiota-related gene set enrichment analysis
1023 -- 1037Zhijie Han 0003, Weiwei Xue, Lin Tao, Yan Lou, Yunqing Qiu, Feng Zhu 0004. Genome-wide identification and analysis of the eQTL lncRNAs in multiple sclerosis based on RNA-seq data
1038 -- 1046Sijia Zhang, Le Zhao, Chun-Hou Zheng, Junfeng Xia. A feature-based approach to predict hot spots in protein-DNA binding interfaces
1047 -- 1057Zhen Chen, Pei Zhao, Fuyi Li, Tatiana T. Marquez-Lago, André Leier, Jerico Nico De Leon Revote, Yan Zhu, David R. Powell, Tatsuya Akutsu, Geoffrey I. Webb, Kuo-Chen Chou, Alexander Ian Smith, Roger J. Daly, Jian Li, Jiangning Song. iLearn : an integrated platform and meta-learner for feature engineering, machine-learning analysis and modeling of DNA, RNA and protein sequence data
1058 -- 1068Qingxia Yang, Bo Li, Jing Tang, Xuejiao Cui, Yunxia Wang, Xiaofeng Li, Jie Hu, Yuzong Chen, Weiwei Xue, Yan Lou, Yunqing Qiu, Feng Zhu 0004. Consistent gene signature of schizophrenia identified by a novel feature selection strategy from comprehensive sets of transcriptomic data
1069 -- 1079Fuyi Li, Cunshuo Fan, Tatiana T. Marquez-Lago, André Leier, Jerico Nico De Leon Revote, Cangzhi Jia, Yan Zhu, Alexander Ian Smith, Geoffrey I. Webb, Quanzhong Liu, Leyi Wei, Jian Li, Jiangning Song. PRISMOID: a comprehensive 3D structure database for post-translational modifications and mutations with functional impact
1080 -- 1097Ji Zhang, Meige Guan, Qianliang Wang, Jiajun Zhang, Tianshou Zhou, Xiaoqiang Sun. Single-cell transcriptome-based multilayer network biomarker for predicting prognosis and therapeutic response of gliomas
1098 -- 1114Chia-Ru Chung, Ting-Rung Kuo, Li-Ching Wu, Tzong-Yi Lee, Jorng-Tzong Horng. Characterization and identification of antimicrobial peptides with different functional activities
1115 -- 1117Meik Kunz, Julian Jeromin, Maximilian Fuchs, Jan Christoph, Giulia Veronesi, Michael Flentje, Sarah Nietzer, Gudrun Dandekar, Thomas Dandekar. In silico signaling modeling to understand cancer pathways and treatment responses
1118 -- 0. Corrigendum to: Comprehensive and critical evaluation of individualized pathway activity measurement tools on pan-cancer data

Volume 21, Issue 2

368 -- 394Saurav Mallik, Zhongming Zhao. Graph- and rule-based learning algorithms: a comprehensive review of their applications for cancer type classification and prognosis using genomic data
395 -- 407Tony C. Y. Kuo, Masaomi Hatakeyama, Toshiaki Tameshige, Kentaro K. Shimizu, Jun Sese. Homeolog expression quantification methods for allopolyploids
408 -- 420Ran Su, Jie Hu, Quan Zou 0001, Balachandran Manavalan, Leyi Wei. Empirical comparison and analysis of web-based cell-penetrating peptide prediction tools
421 -- 428Alex Alves Freitas. Investigating the role of Simpson's paradox in the analysis of top-ranked features in high-dimensional bioinformatics datasets
429 -- 440Basant K. Tiwary. Computational medicine: quantitative modeling of complex diseases
441 -- 457Xin Qi, Yuxin Lin, Jiajia Chen, Bairong Shen. Decoding competing endogenous RNA networks for cancer biomarker discovery
458 -- 472Pablo Mier, Lisanna Paladin, Stella Tamana, Sophia Petrosian, Borbála Hajdu-Soltész, Annika Urbanek, Aleksandra Gruca, Dariusz Plewczynski, Marcin Grynberg, Pau Bernadó, Zoltán Gáspári, Christos A. Ouzounis, Vasilis J. Promponas, Andrey V. Kajava, John M. Hancock, Silvio C. E. Tosatto, Zsuzsanna Dosztányi, Miguel A. Andrade-Navarro. Disentangling the complexity of low complexity proteins
473 -- 485Manuel Franco, Juana-María Vivo, Manuel Quesada-Martínez, Astrid Duque-Ramos, Jesualdo Tomás Fernández-Breis. Evaluation of ontology structural metrics based on public repository data
486 -- 497Xiangrong Liu, Zengyan Hong, Juan Liu 0003, Yuan Lin, Alfonso Rodríguez-Patón, Quan Zou 0001, Xiangxiang Zeng. Computational methods for identifying the critical nodes in biological networks
498 -- 510Xu Zhou, Enyu Dai, Qian Song, Xueyan Ma, Qianqian Meng, Yongshuai Jiang, Wei Jiang. In silico drug repositioning based on drug-miRNA associations
511 -- 526Abukari Mohammed Yakubu, Yi-Ping Phoebe Chen. Ensuring privacy and security of genomic data and functionalities
527 -- 540Giulia Simoni, Hong Thanh Vo, Corrado Priami, Luca Marchetti. A comparison of deterministic and stochastic approaches for sensitivity analysis in computational systems biology
541 -- 552Cecile Chauvel, Alexei Novoloaca, Pierre Veyre, Frédéric Reynier, Jeremie Becker. Evaluation of integrative clustering methods for the analysis of multi-omics data
553 -- 565John J. Dziak, Donna L. Coffman, Stephanie T. Lanza, Runze Li, Lars S. Jermiin. Sensitivity and specificity of information criteria
566 -- 583Xingyi Li, Wenkai Li, Min Zeng, Ruiqing Zheng, Min Li 0007. Network-based methods for predicting essential genes or proteins: a survey
584 -- 594Martin Ayling, Matthew D. Clark, Richard M. Leggett. New approaches for metagenome assembly with short reads
595 -- 608Man Cao, Guodong Chen, Jialin Yu, Shao-Ping Shi. Computational prediction and analysis of species-specific fungi phosphorylation via feature optimization strategy
609 -- 620Hui-fang Liu, Rong Liu. Structure-based prediction of post-translational modification cross-talk within proteins using complementary residue- and residue pair-based features
621 -- 636Jing Tang, Jianbo Fu, Yunxia Wang, Bo Li, Yinghong Li, Qingxia Yang, Xuejiao Cui, Jiajun Hong, Xiaofeng Li, Yuzong Chen, Weiwei Xue, Feng Zhu 0004. ANPELA: analysis and performance assessment of the label-free quantification workflow for metaproteomic studies
637 -- 648Aritro Nath, Paul Geeleher, R. Stephanie Huang. Long non-coding RNA transcriptome of uncharacterized samples can be accurately imputed using protein-coding genes
649 -- 662Ying-Hong Li, Xiao Xu Li, Jiajun Hong, Yun-Xia Wang, Jian Bo Fu, Hong Yang, Chun-yan Yu, Feng Cheng Li, Jie Hu, Wei Wei Xue, Yu Yang Jiang, Yu Zong Chen, Feng Zhu 0004. Clinical trials, progression-speed differentiating features and swiftness rule of the innovative targets of first-in-class drugs
663 -- 675Hyung Yong Kim, Hee-Joo Choi, Jeong-Yeon Lee, Gu Kong. Cancer Target Gene Screening: a web application for breast cancer target gene screening using multi-omics data analysis
676 -- 686Siyuan Chen, Chengzhi Ren, Jingjing Zhai, Jiantao Yu, Xuyang Zhao, Zelong Li, Ting Zhang, Wenlong Ma, Zhaoxue Han, Chuang Ma. CAFU: a Galaxy framework for exploring unmapped RNA-Seq data
687 -- 698Ran Su, Xinyi Liu, Leyi Wei. MinE-RFE: determine the optimal subset from RFE by minimizing the subset-accuracy-defined energy
699 -- 708Cong Pian, Guang-Le Zhang, Libin Gao, Xiaodan Fan, Fei Li. miR+Pathway: the integration and visualization of miRNA and KEGG pathways
709 -- 718Yunxia An, Nan Wei, Xiangsong Cheng, Ying Li, Haiyang Liu, Jia Wang, Zhiwei Xu, Zhifu Sun, Xiaoju Zhang. MCAM abnormal expression and clinical outcome associations are highly cancer dependent as revealed through pan-cancer analysis
719 -- 728Azza E. Ahmed, Ayah A Awadallah, Mawada Tagelsir, Maram A Suliman, Atheer Eltigani, Hassan Elsafi, Basil D. Hamdelnile, Mohamed A Mukhtar, Faisal M. Fadlelmola. Delivering blended bioinformatics training in resource-limited settings: a case study on the University of Khartoum H3ABioNet node
729 -- 740Helena Cirenajwis, Martin Lauss, Maria Planck, Johan Vallon-Christersson, Johan Staaf. Performance of gene expression-based single sample predictors for assessment of clinicopathological subgroups and molecular subtypes in cancers: a case comparison study in non-small cell lung cancer
741 -- 750Zhi Ruan, Yunsong Yu, Ye Feng. The global dissemination of bacterial infections necessitates the study of reverse genomic epidemiology
751 -- 0. Corrigendum to: Dating admixture events is unsolved problem in multi-way admixed populations
752 -- 0. Corrigendum to: gm RAD: an integrated SNP calling pipeline for genetic mapping with RADseq across a hybrid population

Volume 21, Issue 1

1 -- 10Quan Zou 0001, Gang Lin, Xingpeng Jiang, Xiangrong Liu, Xiangxiang Zeng. Sequence clustering in bioinformatics: an empirical study
11 -- 23Xiaoli Qiang, Chen Zhou, Xiucai Ye, Pufeng Du, Ran Su, Leyi Wei. CPPred-FL: a sequence-based predictor for large-scale identification of cell-penetrating peptides by feature representation learning
24 -- 35Mark N. Read, Kieran Alden, Jon Timmis, Paul S. Andrews. Strategies for calibrating models of biology
36 -- 46Sangsoo Lim, Sangseon Lee, Inuk Jung, SungMin Rhee, Sun Kim. Comprehensive and critical evaluation of individualized pathway activity measurement tools on pan-cancer data
47 -- 61Xing Chen, Na-Na Guan, Ya-Zhou Sun, Jian-qiang Li, Jia Qu. MicroRNA-small molecule association identification: from experimental results to computational models
62 -- 72Martin Siebenhaller, Sune S. Nielsen, Fintan McGee, Irina Balaur, Charles Auffray, Alexander Mazein. Human-like layout algorithms for signalling hypergraphs: outlining requirements
73 -- 84Liu Qin, Yanhong Liu, Menglong Li, Xuemei Pu, Yanzhi Guo. The landscape of miRNA-related ceRNA networks for marking different renal cell carcinoma subtypes
85 -- 95Hong Wang, Xiaoyan Lu, Fukun Chen, Yu Ding, Hewei Zheng, Lianzong Wang, Guosi Zhang, Jiaxin Yang, Yu Bai, Jing Li, Jingqi Wu, Meng Zhou, Liangde Xu. Landscape of SNPs-mediated lncRNA structural variations and their implication in human complex diseases
96 -- 105Jamie J. Alnasir, Hugh P. Shanahan. The application of Hadoop in structural bioinformatics
106 -- 119Leyi Wei, Jie Hu, Fuyi Li, Jiangning Song, Ran Su, Quan Zou 0001. Comparative analysis and prediction of quorum-sensing peptides using feature representation learning and machine learning algorithms
120 -- 134Tianlei Xu, Xiaoqi Zheng, Ben Li, Peng Jin, Zhaohui S. Qin, Hao Wu 0003. A comprehensive review of computational prediction of genome-wide features
135 -- 143Qinjie Chu, Panpan Bai, Xintian Zhu, Xingchen Zhang, Lingfeng Mao 0002, Qian-Hao Zhu, Longjiang Fan, Chu-Yu Ye. Characteristics of plant circular RNAs
144 -- 155Emile R. Chimusa, Joel Defo, Prisca K. Thami, Denis Awany, Delesa D. Mulisa, Imane Allali, Hassan Ghazal, Ahmed Moussa, Gaston K. Mazandu. Dating admixture events is unsolved problem in multi-way admixed populations
156 -- 170Haitao Yang, Hongyan Cao, Tao He, Tong Wang, Yuehua Cui. Multilevel heterogeneous omics data integration with kernel fusion
171 -- 181Chuan Dong, Yan-Ting Jin, Hong-Li Hua, Qing-Feng Wen, Sen Luo, Wen-Xin Zheng, Feng-Biao Guo. Comprehensive review of the identification of essential genes using computational methods: focusing on feature implementation and assessment
182 -- 197Chang Su, Jie Tong, Yongjun Zhu, Peng Cui 0001, Fei Wang 0001. Network embedding in biomedical data science
198 -- 210Fei Liu 0006, Monika Heiner, David R. Gilbert. Fuzzy Petri nets for modelling of uncertain biological systems
211 -- 220ZiaurRehman Tanoli, Zaid Alam, Aleksandr Ianevski, Krister Wennerberg, Markus Vähä-Koskela, Tero Aittokallio. Interactive visual analysis of drug-target interaction networks using Drug Target Profiler, with applications to precision medicine and drug repurposing
248 -- 261Jifan Shi, Andrew E. Teschendorff, Weiyan Chen, Luonan Chen, Tiejun Li. Quantifying Waddington's epigenetic landscape: a comparison of single-cell potency measures
262 -- 271Michiel Stock, Tapio Pahikkala, Antti Airola, Willem Waegeman, Bernard De Baets. Algebraic shortcuts for leave-one-out cross-validation in supervised network inference
272 -- 281Adriana Pitea, Ivan Kondofersky, Steffen Sass, Fabian J. Theis, Nikola S. Müller, Kristian Unger. Copy number aberrations from Affymetrix SNP 6.0 genotyping data - how accurate are commonly used prediction approaches?
282 -- 297Chao Shen, Zhe Wang, Xiaojun Yao, Youyong Li, Tailong Lei, Ercheng Wang, Lei Xu, Feng Zhu 0004, Dan Li, Tingjun Hou. Comprehensive assessment of nine docking programs on type II kinase inhibitors: prediction accuracy of sampling power, scoring power and screening power
298 -- 308Bin Liu 0014, Shuangyan Jiang, Quan Zou 0001. HITS-PR-HHblits: protein remote homology detection by combining PageRank and Hyperlink-Induced Topic Search
309 -- 317Zhenyu Yue, Le Zhao, Junfeng Xia. dbCPM: a manually curated database for exploring the cancer passenger mutations
318 -- 328Feng-Xu Wu, Fan Wang, Jing-Fang Yang, Wen Jiang, Meng-Yao Wang, Chen-Yang Jia, Ge-Fei Hao, Guangfu Yang. AIMMS suite: a web server dedicated for prediction of drug resistance on protein mutation
329 -- 337Dan Yao, Hainan Wu, Yuhua Chen, Wenguo Yang, Hua Gao, Chunfa Tong. gmRAD: an integrated SNP calling pipeline for genetic mapping with RADseq across a hybrid population
338 -- 347Quanhu Sheng, David C. Samuels, Hui Yu, Scott Ness, Ying-Yong Zhao, Yan Guo. Cancer-specific expression quantitative loci are affected by expression dysregulation
348 -- 354Sameer Salunkhe, Naren Chandran, Pratik Chandrani, Amit Dutt, Shilpee Dutt. CytoPred: 7-gene pair metric for AML cytogenetic risk prediction
355 -- 367Eugenio Del Prete, Angelo M. Facchiano, Pietro Liò. Bioinformatics methodologies for coeliac disease and its comorbidities